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Review | 26-July-2017

Immune dysfunction and neuroinflammation in autism spectrum disorder

, monocytes, natural killer cells, and dendritic cells. Also, many individuals diagnosed with ASD have alterations in immunoglobulins and increased autoantibodies. Finally, a significant portion of individuals diagnosed with ASD have elevated peripheral cytokines and chemokines and associated neuroinflammation. In conclusion, immune dysregulation and inflammation are important components in the diagnosis and treatment of ASD.

Geir Bjørklund, Khaled Saad, Salvatore Chirumbolo, Janet K. Kern, David A. Geier, Mark R. Geier, Mauricio A. Urbina

Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 4, 257–268

Hypothesis | 30-August-2017

Do minocycline and other suppressors of microglia reactivity have a future in prevention or treatment of epilepsy?

will discuss new concepts of epileptogenesis which focus not only on changes in neurons but also take into consideration the role of activation of glial cells: microglia and astrocytes. Neuroinflammation, mainly through increased production of pro-inflammatory factors such as cytokines or chemokines, may play an important role in the development of epilepsy. Drugs regulating glial cells activation and consequently inflammatory status in the central nervous system have beneficial effects in

Władysław Lasoń, Joanna Ślusarczyk, Magdalena Regulska, Monika Leśkiewicz, Agnieszka Basta-Kaim

Journal of Epileptology, Volume 25 , ISSUE 1-2, 9–20

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