Separation of multiple antibodies by adsorption with allogeneic red blood cells

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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Volume 33 (2020)
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VOLUME 33 , ISSUE 4 (Mar 2020) > List of articles

Separation of multiple antibodies by adsorption with allogeneic red blood cells

E.M. Ekema *

Keywords : multiple antibodies, adsorption, allogeneic red blood cells, antibody identification

Citation Information : Immunohematology. Volume 33, Issue 4, Pages 155-158, DOI: https://doi.org/10.21307/immunohematology-2019-022

License : (CC-BY-NC-ND 4.0)

Published Online: 30-March-2020

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ABSTRACT

Antibody detection and identification are processes that are commonly performed in the transfusion service before transfusion of allogeneic red blood cells (RBCs). Antibody identification usually follows the discovery of a positive antibody detection test, or other factors such as ABO serum/cell discrepancy or an incompatible crossmatch. Antibody identification is a necessary practice in blood banking to determine the suitability of blood products for transfusion on an individual basis. When the presence of multiple antibodies is suspected, several methods, including neutralization of patient’s plasma, titration, elution, chemical or enzyme treatment of reagent RBCs, and adsorption with allogeneic RBCs, may be used to separate and properly identify other atypical antibodies that are present in a single serum or plasma sample. This review will focus on the use of allogeneic adsorption to identify antibody specificities in a patient’s sample.

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